Publications

2013

• Azpurua J, Yang JN, Van Meter M, Liu Z, Kim J, Ladd AL, Coppi AA, Gorbunova V, Seluanov A. (2013) IGF1R levels in the brain negatively correlate with longevity in 16 rodent species. Aging, 5(4):304-14.

2012

• Van Meter M, Seluanov A, Gorbunova V. (2012) Forever young? Exploring the link between rapamycin, longevity and cancer. Cell Cycle, 11(23):4296-7. doi: 10.4161/cc.22868.
• Gorbunova V, Hine C, Tian X, Ablaeva J, Gudkov AV, Nevo E, Seluanov A. (2012) Cancer resistance in the blind mole rat is mediated by concerted necrotic cell death mechanism. Proc Natl Acad Sci, 109(47):19392-6. doi: 10.1073/pnas.1217211109.
• Mao Z., Ke Z., Gorbunova V., and Seluanov A. (2012) Replicatively senescent cells are arrested in G1 and G2 phases. Aging, 4(6):431-5.
• Mao Z., Tian X., VanMeter M., Gorbunova V., and Seluanov A. (2012) Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence. Proc. Natl. Acad. Sci. USA, 109(29):11800-5. doi: 10.1073/pnas.1200583109.
• Rahman I, Kinnula VL, Gorbunova V, Yao H. (2012). SIRT1 as a therapeutic target in inflammaging of the pulmonary disease. Prev Med. 2012 54 Suppl:S20-8
• Hine C., Seluanov A., Gorbunova V. (2012) Rad51 promoter targeted gene therapy is effective for in vivo visualization and treatment of cancer. Molecular therapy, 20(2):347-55

2011

• Fong, V., Osterbur M., Kim Y., Hine C., Gorbunova V., Seluanov A., and Dewhurst S. (2011) Adenoviral vector driven by a minimal Rad51 promoter is selective for p53-deficient tumor cells. PLOS One, 6(12):e28714
• VanMeter M., Mao Z., Gorbunova V., and Seluanov A. (2011). Repairing split ends: SIRT6, mono-ADP ribosylation and DNA repair. Aging, 3(9):829-35
• VanMeter M., Mao Z., Gorbunova V., and Seluanov A. (2011). SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells. Cell Cycle, 10(18):3153-8
• Mao Z, Hine C, Tian X, Van Meter M, Au M, Vaidya A, Seluanov A, Gorbunova V. (2011) SIRT6 promotes DNA repair under stress by activating PARP1. Science , Jun 17;332(6036):1443-6.

2010 and older

• Seluanov A, Vaidya A, Gorbunova V. (2010) Establishing primary adult fibroblast cultures from rodents. J Vis Exp. , Oct 5;(44). 10.3791/2033.
• Seluanov A, Mao Z, Gorbunova V. (2010) . Analysis of DNA double-strand break (DSB) repair in mammalian cells. J Vis Exp. Sep 8;(43). 10.3791/2002.
• Seluanov A, Hine C, Azpurua J, Feigenson M, Bozzella M, Mao Z, Catania KC, Gorbunova V. (2009) Hypersensitivity to contact inhibition provides a clue to cancer resistance of naked mole-rat. Proc Natl Acad Sci U S A. Nov 17;106(46):19352-7.
• Mao Z, Jiang Y, Liu X, Seluanov A, Gorbunova V. (2009) DNA repair by homologous recombination, but not by nonhomologous end joining, is elevated in breast cancer cells. Neoplasia. Jul;11(7):683-91.
• Gorbunova V, Seluanov A. (2009) Coevolution of telomerase activity and body mass in mammals: from mice to beavers. Mech Ageing Dev. 2009 Jan-Feb;130(1-2):3-9. Review.
• Hine CM, Seluanov A, Gorbunova V. (2008) Use of the Rad51 promoter for targeted anti-cancer therapy. Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20810-5.
• Seluanov A, Hine C, Bozzella M, Hall A, Sasahara TH, Ribeiro AA, Catania KC, Presgraves DC, Gorbunova V. (2008) Distinct tumor suppressor mechanisms evolve in rodent species that differ in size and lifespan. Aging Cell. 2008 Dec;7(6):813-23. Epub 2008 Sep 5.
• Mao Z, Bozzella M, Seluanov A, Gorbunova V. (2008) DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells. Cell Cycle. 2008 Sep 15;7(18):2902-6.
• Mao Z, Bozzella M, Seluanov A, Gorbunova V. (2008) Comparison of nonhomologous end joining and homologous recombination in human cells. DNA Repair (Amst). 2008 Oct 1;7(10):1765-71. Epub 2008 Aug 20.
• Gorbunova V, Bozzella MJ, Seluanov A. (2008) Rodents for comparative aging studies: from mice to beavers. Age (Dordr). 2008 Sep;30(2-3):111-9. Jun 25
• Dion V., Lin Y., Price B.A., Fyffe S.L., Seluanov A., Gorbunova V., and Wilson J.H. (2008) Genome-wide demethylation promotes triplet repeat instability independently of homologous recombination. DNA Repair (Amst)., 7(2):313-20.
• Seluanov A., Danek J., House N., and Gorbunova V. (2007) Changes in the level and distribution of Ku proteins during cellular senescence. DNA Repair (Amst), 6(12):1740-8
• Gorbunova V., Seluanov A., Mao Z., and Hine C. (2007) Changes in DNA repair during aging. Nucleic Acids Res., 35(22):7466-74 (Invited review)
• Mao Z., Seluanov A., Jiang Y., and V. Gorbunova (2007) TRF2 is required for repair of non-telomeric DNA double-strand breaks by homologous recombination. Proc. Natl. Acad. Sci, 104(32):13068-73.
• Seluanov A., Chen Z., Hine C., Sasahara T.H.C., Ribeiro A.A.C.M., Catania K.C., Presgraves D.C., and V. Gorbunova (2007) Telomerase Activity Coevolves with Body Mass not Lifespan. Aging Cell, 6(1) pp.45-52
• Shi X., Seluanov A., and V. Gorbunova V. (2006). Cell divisions are required for L1 retrotransposition. Mol. Cell. Biol.
• Gorbunova, V. and A. Seluanov. (2005.) Making ends meet in old age: DSB repair and aging. Mech. Aging. Dev 126(6-7): 621-628.
• Seluanov, A., Mittelman, D., Pereira-Smith, O.M., Wilson, J.H., and V. Gorbunova. (2004). DNA repair by nonhomologous end joining becomes less efficient and more error-prone during cellular senescence. Proc. Natl. Acad. Sci, USA 101(20): 7624-7629.
• Gorbunova, V., Seluanov, A., Mittelman, D. and J.H. Wilson. (2004). Genome-wide demethylation destabilizes CTG*CAG trinucleotide repeats in mammalian cells. Human Molecular Genetics 13(23): 2979-2989.
• Gorbunova, V., and A. Seluanov. (2003). Telomerase as a growth promoting factor. Cell Cycle 2(6): 534-537.
• Gorbunova, V., Seluanov, A., Dion, V., Sandor, Z., Meservy, J.L., and J.H. Wilson. (2003). Selectable system for monitoring the instability of CTG*CAG triplet repeats in mammalian cells. Mol. Cell Biol. 23(13): 4485-4493.
• Gorbunova, V., Seluanov, A., and O.M. Pereira-Smith. (2003). Evidence that high telomerase activity may induce a senescent-like growth arrest in normal human fibroblasts. J. Biol. Chem. 278(9): 7692-7698.
• Gorbunova V., Seluanov A., and O.M. Pereira-Smith. (2002). Expression of hTERT protects normal human fibroblasts from stress-induced apoptosis and necrosis but does not prevent stress-induced premature senescence. J. Biol. Chem. 277(41): 38540-38549.
• Gorbunova V. and A. Seluanov. (2002). CLK-1 protein has DNA binding activity specific to O_L region of mitochondrial DNA. FEBS Lett. 516(1-3): 279-284.
• Seluanov, A., Gorbunova, V., Falcovitz, A., Sigal, A., Milyavsky, M., Zurer., I., Shohat, G., Goldfinger, N. and V. Rotter. (2001). Change of the death pathway in senescent human fibroblasts in response to DNA damage is caused by an inability to stabilize p53 Mol. Cell Biol. 21(5): 1552-1564.
• Gorbunova, V., Avivi-Ragolski, N., Shalev, G., Kovalchuk, I., Abbo, S., Hohn, B. and A.A. Levy. (2000). A new hyperrecombinogenic mutant of nicotiana tabacum. Plant J. 24(5): 601-11.
• Gorbunova, V. and A.A. Levy. (2000). Analysis of extrachromosomal Ac/Ds transposable elements Genetics 155(1): 349-359.
• Gorbunova, V., Ramos, C., Hohn, B., and A.A. Levy. (2000). A nuclear protein that binds specifically to several maize transposons is not essential for Ds1 excision. Mol. Gen. Genet. 263(3): 492-497.
• Gorbunova, V. and A.A. Levy. (1999). How plants make ends meet: DNA double-strand break repair Trends Plant Sci. 4(7): 263-269.
• Gorbunova, V. and A.A. Levy. (1997). Nonhomologous DNA end joining in plant cells is associated with deletions and filler DNA insertions. Nucleic Acids Res. 25: 4650-4657.
• Gorbunova, V. and A.A. Levy. (1997). Circularized Ac/Ds transposons: formation, structure and fate Genetics 145: 1161-1169.

Content last modified: May 13, 2013